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Lipochroman-6




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Lipochroman-6
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Lipochroman-6
CAS No. 83923-51-7

Radicals and reactive species are responsible for several mechanisms which trigger skin aging. They cause irreversible damage in cells and tissues, affecting organs too, so they are involved in a great number of diseases. In particular, Peroxynitrite, a powerful RNS (Reactive Nitrogen Species), exhibits a wide array of tissue-harmful effects, ranging from lipid peroxidation and DNA damage to inactivation of enzymes via protein oxidation and nitration. ROS (Reactive Oxygen Species) are free radicals generated from endogenous sources and also from external pro-oxidant stimuli.

Lipochroman-6, is a remarkable molecule that can capture both nitrogen and oxygen radicals. In addition to this dual activity, Lipochroman-6 is one of the most potent oxygen-radical scavengers. It is, therefore, a powerful active to prevent skin cell damage produced by several kinds of radicals and reactive species.

Oxidative stress is the imbalance between cellular production of free radical species and the ability of cells to eliminate them employing endogenous antioxidant defense mechanisms. This stress damages cells irreversibly. Cellular level studies of Lipochroman-6 as compared to Resveratrol, Vitamin E and Ferulic Acid in cell viability assays indicate it increased cell viability by as much as 173% compared to these materials. The use of Lipochroman-6 in cosmetic formulations can significantly reduce oxidative stress.

Cosmetic Benefits

  • Double scavenging action: RNS and ROS
  • Potent singlet oxygen scavenging activity
  • Potent inhibitor or Peroxynitrite-induced lipid peroxidation
  • Prevents skin cell damage induced by peroxynitrite and nitric oxide formation
  • Internal photo-protection against UVA light by inhibiting ROS production
  • Inhibits lipid peroxidation at low concentrations
  • Avoids lipid peroxidation of essential oils in cosmetic formulations
  • Protects human fibroblasts against oxidative stress

Cosmetic Applications

Lipochroman-6 can be incorporated in oil-containing cosmetic formulations such as emulsions, gels, sera, etc., where premature skin aging avoidance is desired.

Formulation Guidelines

  • Easily incorporated in cosmetic formulations dissolved in the appropriate solvent.
  • It is recommended to add the product in the oily phase, at the final stage of the manufacturing process. Although it can be incorporated at a maximum temperature of 70°C (158°F), if formulated with oxidant agents the temperature should be lowered.

Recommended Usage Rate: 0.01 - 0.05% (0.01 - 0.05gm per 100gm)


Appearance: Off white to beige crystalline powder
Molecular Weight: 208.25 Daltons
Solubility: Soluble in alcohol, Polysorbate 20, PEG-8 Caprylic/Capric, DMI, Ethoxydiglycol, among others (see Technical Data Sheet)
Manufacturer: Lipotec
Country of Origin: Spain
Storage: Store in cool, dry and clean place in original container away from light and moisture.
Shelf life: 30 Months, properly stored.

INCI: Dimethylmethoxy Chromanol

Shipping Information: HS Code 2909505000

Disclaimer
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm.

Here you will find Safety Data Sheets (SDS) and Technical Data Sheets. The files are in PDF format. To access a file, click on the relevant button or the file name. For your convenience, it will open up in a new browser window.

Please note: You must have Acrobat Reader to view the files listed here. If necessary, the Acrobat Reader link will directed you to a page where it can be downloaded.

Technical Data
Lipochroman-6 Brochure
Lipochroman-6 Technical Presentation
Lipochroman-6 Marketing Presentation

Safety Data Sheet (SDS)
Lipochroman-6 SDS

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News
05-25-2018
So that our staff may enjoy the Memorial Day Holiday, Lotioncrafter's offices will be closed on Monday, May 28th. We will reopen on Tuesday, May 29th. During this time, we will not be returning phone calls or email messages. Shipping will resume on Tuesday, May 29th. Orders, emails and phone calls will be handled in the order received, as best we are able. Please expect some delays as we work through the holiday backlog! We also cannot guarantee changes to orders will be seen before orders have shipped, those that we do catch, will be held back to adjust, which will mean a shipping delay. We appreciate your understanding. Have a safe and happy Memorial Day!

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